How Do You Spell PROTEIN FARNESYLATION?

Pronunciation: [pɹˈə͡ʊtiːn fˌɑːnɪsɪlˈe͡ɪʃən] (IPA)

Protein Farnesylation is a biochemical process that involves the addition of a farnesyl lipid moiety to the cysteine residue of a protein. The spelling of the word "Farnesylation" can be broken down phonetically using the International Phonetic Alphabet (IPA) as fɑːnɛsɪleɪʃən. The stressed syllable is marked with a long vowel sound, while the "s" sound is written as an "s" as it is unvoiced. The "-tion" ending is pronounced as "ʃən", with the "t" being silent. Overall, the spelling of this complex term reflects the complex process it represents.

PROTEIN FARNESYLATION Meaning and Definition

1. Protein farnesylation is a post-translational modification process that involves the addition of a farnesyl lipid group to a protein molecule. It is a crucial enzymatic reaction that occurs in eukaryotic cells, typically targeting small GTPases, which are key regulators of various cellular processes.

   The farnesyl group consists of a 15-carbon isoprenoid lipid chain, and its attachment to proteins is catalyzed by an enzyme called protein farnesyltransferase (FTase). This modification occurs at a specific cysteine residue near the C-terminus of the protein, and it is essential for the proper cellular functioning of farnesylated proteins.

   Protein farnesylation serves several important roles within the cell. One of its primary functions is to anchor farnesylated proteins to cell membranes, specifically the inner surface of the plasma membrane or the membranes of various organelles. This membrane association allows the farnesylated proteins to participate in critical cellular processes, including signal transduction, cell cycle regulation, and intracellular trafficking.

   Furthermore, protein farnesylation plays a significant role in mediating protein-protein interactions. It enables farnesylated proteins to interact with other cellular components, such as other proteins or lipids, through specific binding domains. These interactions are vital for the proper localization, activation, and downstream signaling of farnesylated proteins.

   In summary, protein farnesylation is a process by which a farnesyl lipid group is attached to a protein molecule, primarily small GTPases. This modification facilitates membrane association, protein-protein interactions, and various cellular processes, making it a crucial mechanism in cell biology.

Common Misspellings for PROTEIN FARNESYLATION

• orotein farnesylation
• lrotein farnesylation
• -rotein farnesylation
• 0rotein farnesylation
• peotein farnesylation
• pdotein farnesylation
• pfotein farnesylation
• ptotein farnesylation
• p5otein farnesylation
• p4otein farnesylation
• pritein farnesylation
• prktein farnesylation
• prltein farnesylation
• prptein farnesylation
• pr0tein farnesylation
• pr9tein farnesylation
• prorein farnesylation
• profein farnesylation
• progein farnesylation
• proyein farnesylation

Etymology of PROTEIN FARNESYLATION

The word "protein farnesylation" has its etymology rooted in the scientific field of biochemistry and molecular biology.

The term "protein" comes from the French word "protéine", which was coined in 1838 by Dutch chemist Gerhard Mulder. Mulder used the term to describe a class of nitrogenous substances that were essential components of living organisms.

"Farnesylation" refers to a specific type of post-translational modification (PTM) that involves the addition of a farnesyl lipid group to a protein molecule. Farnesyl refers to a 15-carbon isoprenoid molecule called farnesyl pyrophosphate, which is the donor molecule in this modification process. This term is derived from "farnesene", a hydrocarbon compound found in some natural products, initially isolated from farnesol, a constituent of various essential oils.