Progressive Relapsing Multiple Sclerosis (PRMS) is a subtype of multiple sclerosis (MS), a chronic neurological disease that affects the central nervous system. PRMS is characterized by a combination of steady disease progression and acute relapses. It is considered the least common form of MS, accounting for only about 5% of all cases.
In PRMS, individuals experience a progressive decline in neurological function, such as increasing disability and worsening symptoms, that gradually worsens over time. Unlike other subtypes of MS, such as relapsing-remitting multiple sclerosis (RRMS) or primary progressive multiple sclerosis (PPMS), the decline in function in PRMS is not marked by periods of remission or stabilization. Instead, relapses or flare-ups occur intermittently, causing sudden aggravation or intensity of symptoms. These relapses may include the reappearance of previously experienced symptoms or the emergence of new ones.
The symptoms of PRMS can vary widely depending on the area of the nervous system affected and may include problems with motor function, cognition, coordination, sensation, vision, and bowel or bladder function. Due to the progressive nature of PRMS, individuals may gradually experience physical and cognitive impairments, leading to increased disability over time.
Treatment for PRMS often involves the use of disease-modifying therapies to slow disease progression and manage symptoms. However, as PRMS is often more resistant to treatment than other subtypes of MS, the effectiveness of available therapies may be limited, making the management of the disease challenging.
