How Do You Spell PROCOLLAGEN PROLINE DIOXYGENASE?

Pronunciation: [pɹə͡ʊkˈɒle͡ɪd͡ʒən pɹˈɒliːn da͡ɪˈɒksɪd͡ʒənˌe͡ɪs] (IPA)

Procollagen proline dioxygenase is an enzyme that plays a crucial role in modifying collagen proteins. The word is pronounced as /proʊkɒlʌdʒən prəlaɪn daɪɒksɪdʒəneɪz/. The initial "pro" in procollagen refers to the precursor of collagen. The "proline" in proline dioxygenase is an amino acid found in collagen. "Dioxygenase" signifies the enzyme's ability to use two molecules of oxygen to modify prolines in collagen. The spelling of this word is intricate, but it accurately reflects the enzyme's function in collagen biology.

PROCOLLAGEN PROLINE DIOXYGENASE Meaning and Definition

1. Procollagen proline dioxygenase, also known as prolyl hydroxylase, is an enzyme that catalyzes a key step in the biosynthesis of collagen, a fundamental protein found in connective tissues throughout the body. This enzyme is responsible for the hydroxylation of specific proline residues within the procollagen molecule.

   The process of hydroxylation involves the addition of a hydroxyl (-OH) group to the proline amino acid in the collagen chain. This modification is crucial for the subsequent formation of stable collagen triple helices, which provide strength and stability to tissues such as skin, tendons, and bones.

   Procollagen proline dioxygenase requires molecular oxygen (O2) as a substrate and uses iron and ascorbic acid (vitamin C) as cofactors to carry out its catalytic function. It specifically targets and hydroxylates proline residues in the Y position of the peptide sequence Gly-X-Y, where X is often another proline and Y is frequently hydroxyproline.

   Deficiency or dysfunction of procollagen proline dioxygenase can lead to disorders such as Ehlers-Danlos syndrome, a group of genetic connective tissue disorders characterized by skin hyperextensibility and joint hypermobility. These conditions arise due to the impaired stability of collagen molecules resulting from the absence of hydroxylation.

   Understanding the role of procollagen proline dioxygenase and its influence on collagen synthesis is crucial for elucidating the molecular mechanisms underlying various connective tissue disorders and may pave the way for potential therapeutic interventions targeting collagen-related pathologies.

Common Misspellings for PROCOLLAGEN PROLINE DIOXYGENASE

• orocollagen proline dioxygenase
• lrocollagen proline dioxygenase
• -rocollagen proline dioxygenase
• 0rocollagen proline dioxygenase
• peocollagen proline dioxygenase
• pdocollagen proline dioxygenase
• pfocollagen proline dioxygenase
• ptocollagen proline dioxygenase
• p5ocollagen proline dioxygenase
• p4ocollagen proline dioxygenase
• pricollagen proline dioxygenase
• prkcollagen proline dioxygenase
• prlcollagen proline dioxygenase
• prpcollagen proline dioxygenase
• pr0collagen proline dioxygenase
• pr9collagen proline dioxygenase
• proxollagen proline dioxygenase
• provollagen proline dioxygenase
• profollagen proline dioxygenase
• prodollagen proline dioxygenase