The spelling of the word "primary sequestrum" is influenced by its phonetic pronunciation. "Primary" is pronounced as "ˈpraɪməri", with stress on the first syllable and ending with an "i" sound. "Sequestrum" is pronounced as "sɪˈkwɛstrəm", with stress on the second syllable and ending with an "um" sound. Together, the word combines the common spelling of "primary" and the phonetic spelling of "sequestrum". It refers to the first area of bone necrosis that occurs in various bone infections.
A primary sequestrum refers to a specific phenomenon that occurs in the context of bone infections, particularly those caused by bacteria. It represents a localized area of dead or devitalized bone, usually resulting from an acute infection that affects a specific bone or bone segment. The primary sequestrum is formed as a response to the infection, acting as a barrier to prevent the spread of infection to adjacent healthy bone tissue.
The process of primary sequestrum formation begins when bacteria penetrate the bone through a small fracture or a surgical incision, initiating an inflammatory response. The immune system tries to contain the infection by creating a localized area of dead bone through the action of osteoclasts and osteoblasts. This area is known as the primary sequestrum.
The primary sequestrum acts as a physical and biological barrier, as dead bone tissue is less vascularized and limits the spread of infection to surrounding healthy bone. In some cases, it may also form a wall around an abscess, confining the infection further.
Treatment of primary sequestrum typically involves surgical removal and debridement of the infected bone, along with administration of appropriate antibiotics. This process allows for eradication of the infection and promotes the formation of new healthy bone tissue.
Understanding the concept of primary sequestrum is crucial in the diagnosis and management of bone infections, as it helps guide appropriate treatment strategies and ensures effective containment and elimination of the infection.
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A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "primary sequestrum" consists of two parts: "primary" and "sequestrum".
1. "Primary" comes from the Latin word "primarius", which means "first" or "chief". It shares the same root as words like "prime" and "primitive" and indicates something that is of utmost importance or initial in nature.
2. "Sequestrum" also comes from Latin and originates from the verb "sequi" meaning "to follow" or "to pursue". In this context, "sequestrum" refers to a fragment of dead bone that has separated from the surrounding healthy bone due to various factors like infection or trauma.
In combination, "primary sequestrum" refers to the first or main fragment of dead bone that has detached or separated from the healthy bone.