PRIBPP SYNTHETASE Meaning and
Definition
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PRibPP synthetase, also known as phosphoribosylpyrophosphate (PRPP) synthetase, is an essential enzyme involved in nucleotide synthesis and salvaging pathways. It plays a critical role in the biosynthesis of purine and pyrimidine nucleotides, which are the building blocks of DNA and RNA.
PRibPP synthetase is responsible for the conversion of ribose 5-phosphate, an intermediate in the pentose phosphate pathway, into PRPP. This reaction involves the transfer of pyrophosphate from ATP to ribose 5-phosphate, resulting in the formation of PRPP and ADP.
PRPP serves as an activated sugar phosphoester that is utilized as a key substrate for numerous enzymatic reactions involved in nucleotide metabolism. It acts as a precursor for the de novo synthesis of purine and pyrimidine nucleotides and is also involved in salvage pathways, where it contributes to the recycling of nucleotides from degradation.
The activity of PRibPP synthetase is tightly regulated to ensure the proper balance of nucleotide biosynthesis. Regulation of this enzyme occurs at multiple levels, including feedback inhibition by end products and allosteric regulation by various effectors.
Deficiency or malfunction of PRibPP synthetase is linked to various human diseases, such as gout, Lesch-Nyhan syndrome, and immunodeficiencies. Additionally, altered expression of this enzyme has been associated with cancer, with overexpression commonly observed in certain malignancies.
In conclusion, PRibPP synthetase is a critical enzyme in nucleotide metabolism, playing a central role in the synthesis and recycling of purine and pyrimidine nucleotides. Its proper function is essential for DNA and RNA synthesis, as well as for
Common Misspellings for PRIBPP SYNTHETASE
- oribpp synthetase
- lribpp synthetase
- -ribpp synthetase
- 0ribpp synthetase
- peibpp synthetase
- pdibpp synthetase
- pfibpp synthetase
- ptibpp synthetase
- p5ibpp synthetase
- p4ibpp synthetase
- prubpp synthetase
- prjbpp synthetase
- prkbpp synthetase
- probpp synthetase
- pr9bpp synthetase
- pr8bpp synthetase
- privpp synthetase
- prinpp synthetase
- prihpp synthetase
- prigpp synthetase
Etymology of PRIBPP SYNTHETASE
The term "PRibPP synthetase" doesn't seem to have a specific etymology itself as it is a combination of various abbreviations and scientific terminology. However, we can break down the components to understand their origins:
1. "PRibPP": PRibPP stands for 5-phospho-D-ribosyl-1-pyrophosphate, which is an intermediate compound in biochemical pathways. The abbreviation PRibPP is derived from its chemical structure.
2. "synthetase": In biology, "synthetase" is used to refer to enzymes that catalyze the synthesis of a compound. The suffix "-ase" means an enzyme, while "synthet" is derived from "synthesize", indicating the enzyme's role.
