How Do You Spell PREMIRNA?
Pronunciation: [pɹˈɛmɜːnə] (IPA) 
Correct spelling for the English word "PREMIRNA" is [pɹˈɛmɜːnə], [pɹˈɛmɜːnə], [p_ɹ_ˈɛ_m_ɜː_n_ə] (IPA phonetic alphabet).
Pronunciation: [pɹˈɛmɜːnə] (IPA)
Correct spelling for the English word "PREMIRNA" is [pɹˈɛmɜːnə], [pɹˈɛmɜːnə], [p_ɹ_ˈɛ_m_ɜː_n_ə] (IPA phonetic alphabet).
PremiRNA, short for precursor microRNA, refers to an RNA molecule that serves as an intermediate step in the production of microRNA (miRNA). MiRNAs are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation by binding to messenger RNA (mRNA) molecules. These miRNAs are derived from larger primary transcripts called pri-miRNAs, which are further processed into pre-miRNAs before becoming mature miRNAs.
PremiRNAs are typically around 70-100 nucleotides in length and are folded into a characteristic hairpin structure. They are initially transcribed from specific genes in the cell nucleus by the process called transcription, using the DNA sequence as a template. The primary transcript undergoes several enzymatic modifications, including the removal of a portion of the RNA molecule to produce the pre-miRNA.
Once processed, the pre-miRNA is exported from the nucleus to the cytoplasm, where it is further processed by an enzyme called Dicer. Dicer cleaves the pre-miRNA into a smaller RNA duplex consisting of a guide strand (the mature miRNA) and a passenger strand (the miRNA*), which is typically degraded. The mature miRNA then associates with the RNA-induced silencing complex (RISC) to guide the complex to target mRNA molecules. This binding can lead to mRNA degradation or translational repression, thus regulating gene expression.
