How Do You Spell PREIMPLANTATION GENETIC DIAGNOSIS?

Pronunciation: [pɹˌa͡ɪmplantˈe͡ɪʃən d͡ʒɛnˈɛtɪk dˌa͡ɪəɡnˈə͡ʊsɪs] (IPA)

Preimplantation Genetic Diagnosis is spelled /pri.ɪmˌplænteɪʃən dʒɪˈnɛtɪk daɪəɡˈnəʊsɪs/. The first syllable is pronounced with a long "i" sound, while the second syllable has a short "i" sound. The third syllable, "plant," uses a schwa sound before the "t" sound. The stress falls on the fourth syllable, "ta," and the fifth syllable, "sic," is pronounced as "sih." The sixth syllable has a short "o" sound before ending with a "sis" sound. This complex term is used to describe testing embryos for genetic disorders prior to in vitro fertilization.

PREIMPLANTATION GENETIC DIAGNOSIS Meaning and Definition

1. Preimplantation Genetic Diagnosis (PGD) is a specialized reproductive technology that involves the testing of embryos created through in vitro fertilization (IVF) for genetic abnormalities before they are implanted in the uterus. This diagnostic procedure is primarily used to identify genetic disorders or chromosomal abnormalities in embryos before they are transferred to the womb, thereby allowing parents to make informed decisions regarding the selection of embryos for implantation in order to avoid passing on hereditary diseases or conditions.

   PGD involves the extraction of a few cells from the developing embryo, usually on the third day after fertilization, without causing any harm to the embryo's development. These cells are then analyzed to determine if any genetic abnormalities or chromosomal disorders are present. The analysis is carried out using various molecular techniques such as polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), or next-generation sequencing (NGS).

   The results of PGD help geneticists and fertility doctors identify embryos that are free from genetic abnormalities or chromosomal disorders and have the highest potential for successful implantation and development into a healthy pregnancy. This procedure enables couples who are carriers of genetic diseases or have a family history of genetic disorders to have a better chance of having a healthy child.

   Overall, preimplantation genetic diagnosis plays a crucial role in assisting couples in selecting embryos with the best chances of carrying a healthy pregnancy to term and helps to reduce the risk of passing on genetic disorders to their offspring.

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