PPD F, also known as PeriPortal Ductular Reactive Fibrosis, is a medical condition that refers to a specific pattern of fibrosis observed in liver tissue during histological examination. This histological pattern is characterized by the presence of reactive fibrosis around periportal regions of the liver, commonly seen in individuals with chronic liver diseases.
The term "PPD F" is an abbreviation that stands for PeriPortal Ductular Reactive Fibrosis, with the "PPD" referring to the periportal ductular reaction and the "F" indicating the fibrotic process. Periportal ductular reaction involves the proliferation and activation of cells known as ductular cells around the portal tracts of the liver in response to liver injury or disease.
The fibrotic component of PPD F refers to the excessive accumulation of extracellular matrix proteins, particularly collagen, in the periportal areas. This fibrosis can lead to the formation of fibrous bridges between portal tracts, disrupting the normal liver architecture and impairing liver function.
PPD F is commonly observed in various chronic liver diseases, including viral hepatitis, alcoholic liver disease, primary biliary cholangitis, and non-alcoholic fatty liver disease. It represents a pathological response to ongoing liver injury and inflammation, and its presence on liver biopsy can provide valuable insights into the severity and progression of the underlying liver disease.
In summary, PPD F is a histological pattern characterized by reactive fibrosis around periportal regions of the liver in individuals with chronic liver diseases.
