Postencephalitic Economo Type Parkinsonism (PEEP) is a rare neurological disorder that is characterized by symptoms similar to those of Parkinson's disease. It is alternatively referred to as postencephalitic parkinsonism or von Economo disease.
PEEP is believed to be a sequelae of an earlier viral infection, specifically the epidemic encephalitis lethargica that occurred during the early 20th century. This infection affects the brain and can lead to inflammation, particularly in the basal ganglia and substantia nigra regions, which are responsible for regulating movement.
The symptoms of PEEP typically include bradykinesia (slowness of movement), rigidity (stiffness), tremors, and postural instability. These motor impairments can range from mild to severe and often result in significant functional limitations. In addition to motor symptoms, patients may also experience non-motor symptoms such as cognitive impairment, mood disturbances, and autonomic dysfunction.
Diagnosis of PEEP is based on the presentation of characteristic symptoms, a detailed medical history of previous encephalitis infection, and ruling out other possible causes of parkinsonism. Imaging studies, such as magnetic resonance imaging (MRI) or positron emission tomography (PET) scans, may be used to further support the diagnosis.
Management of PEEP focuses on alleviating symptoms and improving quality of life. Treatment may involve the use of medications such as levodopa, which helps increase dopamine levels in the brain. Physical therapy and occupational therapy are also valuable components of management, as they can improve mobility, balance, and functional abilities.
Overall, PEEP is a unique form of parkinsonism that arises from a prior viral infection affecting the brain. It shares many similarities with idiopathic Parkinson's disease but
