PORPHYRINOGEN SYNTHETASE Meaning and
Definition
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Porphyrinogen synthetase is an enzyme that plays a crucial role in the synthesis of porphyrin molecules, which are the building blocks for many essential biological molecules such as heme, chlorophyll, and cytochromes. Porphyrins are a class of organic molecules characterized by a complex cyclic structure called a porphyrin ring.
Porphyrinogen synthetase is responsible for the conversion of porphobilinogen, an intermediate molecule in the synthesis pathway, into porphyrinogen. This enzymatic reaction involves a series of steps that require the incorporation of four molecules of porphobilinogen, resulting in the formation of a tetrapyrrole intermediate called porphyrinogen.
The activity of porphyrinogen synthetase is essential for the normal functioning of living organisms as it ensures the proper production of heme, which is a fundamental component of proteins involved in oxygen transport (hemoglobin), electron transfer (cytochromes), and enzymatic reactions (cytochrome P450 enzymes). Additionally, porphyrinogens are essential precursors for the synthesis of chlorophyll, the pigment responsible for light absorption in plants and algae, enabling photosynthesis.
Deficiencies or mutations in the gene encoding porphyrinogen synthetase can cause a group of genetic disorders collectively known as porphyrias. These disorders are characterized by impaired porphyrin synthesis, leading to the accumulation of certain intermediate molecules and resulting in a wide range of symptoms, including abdominal pain, skin photosensitivity, neurological abnormalities, and even life-threatening acute attacks.
Common Misspellings for PORPHYRINOGEN SYNTHETASE
- oorphyrinogen synthetase
- lorphyrinogen synthetase
- -orphyrinogen synthetase
- 0orphyrinogen synthetase
- pirphyrinogen synthetase
- pkrphyrinogen synthetase
- plrphyrinogen synthetase
- pprphyrinogen synthetase
- p0rphyrinogen synthetase
- p9rphyrinogen synthetase
- poephyrinogen synthetase
- podphyrinogen synthetase
- pofphyrinogen synthetase
- potphyrinogen synthetase
- po5phyrinogen synthetase
- po4phyrinogen synthetase
- porohyrinogen synthetase
- porlhyrinogen synthetase
- por-hyrinogen synthetase
- por0hyrinogen synthetase
Etymology of PORPHYRINOGEN SYNTHETASE
The word "Porphyrinogen Synthetase" has its etymology rooted in Greek and Latin.
The term "porphyrinogen" comes from the Greek word "porphyra" meaning "purple" and the Latin-English suffix "-gen", which indicates a "substance that generates or produces". Porphyrinogens are a class of chemical compounds that form the basic building blocks of porphyrins, which are pigments responsible for the production of heme and chlorophyll.
The word "synthetase" is derived from the Greek word "synthesis" meaning "a putting together" or "a combining". In the context of biochemistry, "synthetase" refers to an enzyme that catalyzes the synthesis or formation of a specific substance.
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