POLYKETIDE SYNTHASE Meaning and
Definition
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Polyketide synthase (PKS) is an enzyme complex involved in the biosynthesis of polyketides, a class of natural products with diverse structures and biological activities. Polyketides are synthesized through a repetitive "assembly line" mechanism, where various individual building blocks are sequentially assembled and modified by the PKS enzyme complex.
The PKS enzyme complex is typically composed of multiple protein subunits, each fulfilling a specific role in the biosynthesis process. These subunits include ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP), among others. Each subunit contributes to the overall catalytic activity of the enzyme complex, allowing the precise assembly of polyketides.
Polyketide synthases can be divided into different types based on their organization and architecture, such as type I, II, and III. Each type of PKS is responsible for synthesizing distinct classes of polyketides. Type I PKSs are large, multi-modular enzymes that operate on a single large polypeptide chain, while type II PKSs consist of individual, single-function enzymes that work together to build the polyketide chain.
Polyketide synthases have been widely studied due to their importance in producing a broad range of bioactive compounds, including antibiotics, anticancer agents, and immunosuppressants. By understanding the mechanisms and functions of these enzymes, researchers can gain insights into the biosynthesis of polyketides and potentially manipulate these processes to generate new and useful compounds for pharmaceutical, agricultural, and industrial applications.
Common Misspellings for POLYKETIDE SYNTHASE
- oolyketide synthase
- lolyketide synthase
- 0olyketide synthase
- pilyketide synthase
- pklyketide synthase
- pllyketide synthase
- pplyketide synthase
- p0lyketide synthase
- p9lyketide synthase
- pokyketide synthase
- popyketide synthase
- pooyketide synthase
- poltketide synthase
- polgketide synthase
- polhketide synthase
- poluketide synthase
- pol7ketide synthase
- pol6ketide synthase
- polyjetide synthase
- polymetide synthase
Etymology of POLYKETIDE SYNTHASE
The word "polyketide synthase" is a combination of multiple components.
"Polyketide" refers to a type of organic compound that contains multiple keto (carbonyl) groups. These compounds are often synthesized by living organisms, particularly bacteria, fungi, and plants. The term "polyketide" itself comes from the combination of "poly-", meaning multiple or many, and "-ketide", referring to the presence of carbonyl groups.
"Synthase" is derived from the word "synthesize", which means to combine or produce a substance through chemical reactions. It is commonly used in biology and biochemistry to describe enzymes involved in the synthesis of complex molecules such as polyketides.
Therefore, "polyketide synthase" refers to an enzyme or group of enzymes responsible for synthesizing polyketides, which are complex organic compounds with multiple keto groups.
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