How Do You Spell POLY ADP RIBOSE TRANSFERASE?

Pronunciation: [pˈɒlɪ ˌe͡ɪdˌiːpˈiː ɹˈɪbə͡ʊz tɹansfˈɜːɹe͡ɪz] (IPA)

Poly ADP Ribose Transferase is a key enzyme involved in DNA repair. Its spelling can be explained through IPA phonetic transcription as /ˈpɒli ˌædˌpiː ˈraɪˌbəʊs ˈtrænsfəreɪs/. Each segment of the word is pronounced with a slight pause in between. Poly is pronounced with two syllables /ˈpɒli/. ADP is pronounced as separate letters /ˌædˌpiː/. Ribose is pronounced as /ˈraɪˌbəʊs/. Transferase is broken up into two syllables with the emphasis on the second syllable, /ˈtrænsfəreɪs/. By breaking the word down into its individual segments, its spelling becomes easier to understand and remember.

POLY ADP RIBOSE TRANSFERASE Meaning and Definition

  1. Poly ADP Ribose Transferase (PARP) is an enzyme that plays a crucial role in several cellular processes, particularly in the regulation of DNA repair and cell death. It catalyzes the transfer of ADP-ribose units from nicotinamide adenine dinucleotide (NAD+) to various protein acceptors, thereby causing post-translational modifications.

    PARP is primarily associated with the repair of single-stranded DNA breaks (SSBs). Upon detection of such breaks, PARP is rapidly activated and binds to the damaged DNA, facilitating the recruitment of repair proteins to the site of injury. By attaching ADP-ribose units to these proteins, PARP helps to promote their proper functioning and coordination, ultimately repairing the DNA damage.

    Additionally, PARP is involved in cellular processes such as chromatin remodeling, transcriptional regulation, and cell death pathways. In cases where DNA damage is extensive and irreparable, PARP can initiate programmed cell death by consuming large amounts of NAD+ and ATP, leading to cellular energy depletion and activation of apoptosis.

    PARP has attracted significant interest in the field of cancer research due to its vital role in DNA repair. Inhibitors of PARP have been developed as potential therapeutic agents for various cancers, including those with defects in DNA repair mechanisms such as BRCA-mutated tumors.

    Overall, PARP is an essential enzyme that contributes to the maintenance of genome stability, cell survival, and regulation of various cellular processes.

Common Misspellings for POLY ADP RIBOSE TRANSFERASE

  • ooly adp ribose transferase
  • loly adp ribose transferase
  • -oly adp ribose transferase
  • 0oly adp ribose transferase
  • pily adp ribose transferase
  • pkly adp ribose transferase
  • plly adp ribose transferase
  • pply adp ribose transferase
  • p0ly adp ribose transferase
  • p9ly adp ribose transferase
  • poky adp ribose transferase
  • popy adp ribose transferase
  • pooy adp ribose transferase
  • polt adp ribose transferase
  • polg adp ribose transferase
  • polh adp ribose transferase
  • polu adp ribose transferase
  • pol7 adp ribose transferase
  • pol6 adp ribose transferase
  • poly zdp ribose transferase

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