POEMS syndrome is a rare disorder, characterized by the presence of monoclonal plasma cells and the occurrence of peripheral neuropathy, organomegaly, endocrinopathy, M protein, and skin changes. The acronym "POEMS" stands for these five features. The correct spelling of "POEMS" is /pəʊmz/ as in "pohms." The "o" is pronounced like "oh," the "e" is pronounced like "eh," and the "s" is pronounced like "z." Accurate spelling and pronunciation of medical terms are essential for effective communication among healthcare professionals.
POEMS syndrome, also known as osteosclerotic myeloma, is a rare and complex multisystem disorder characterized by the presence of various symptoms. The name an acronym for the different features associated with the syndrome: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes.
The first component, polyneuropathy, refers to damage to multiple peripheral nerves throughout the body. This may cause symptoms such as numbness, tingling, weakness, or pain in the extremities. Organomegaly indicates abnormal enlargement of organs, most commonly the liver and spleen. Endocrinopathy refers to the presence of hormone-related disorders, such as diabetes, hypothyroidism, or adrenal gland dysfunction. The "M protein" component signifies the presence of a monoclonal gammopathy, which is an excess production of abnormal plasma cells in the bone marrow. Lastly, skin changes may include a variety of manifestations like hyperpigmentation, thickened skin, or excessive hair growth.
Individuals with POEMS syndrome may also experience additional symptoms such as edema, fatigue, unexplained weight loss, respiratory difficulties, or changes in vision. The exact cause of POEMS syndrome is currently unknown, but it is believed to be associated with the overgrowth of plasma cells and the release of certain chemicals that contribute to the specific symptoms observed.
Diagnosis of POEMS syndrome typically involves a combination of medical history assessment, physical examination, blood tests, imaging studies, and a biopsy of affected tissues. Treatment options for this syndrome often involve addressing the underlying plasma cell disorder and managing individual symptoms. This may include chemotherapy, radiation therapy, stem cell transplantation, corticosteroids, or medications targeted at specific symptoms.
Overall, POEMS syndrome is a rare
The acronym POEMS stands for Polyneuropathy, Organomegaly, Endocrinopathy,al gammopathy, and Skin changes. This syndrome was first recognized and described in 1980 by Dr. Crow and his colleagues, who named it POEMS syndrome to highlight its characteristic features.
The etymology of the word "POEMS" itself comes from the initial letters of the key clinical features associated with the syndrome:
1. Polyneuropathy: Refers to a disorder that affects multiple peripheral nerves, leading to symptoms such as numbness, tingling, weakness, and pain.
2. Organomegaly: Describes the abnormal enlargement of organs, particularly the liver, spleen, and lymph nodes.
3. Endocrinopathy: Refers to a disorder affecting the endocrine system, which includes glands like the thyroid, adrenal, and pituitary glands, among others.