Pneumonia Virus of Mice (PVM) is a highly contagious and pathogenic virus that primarily affects laboratory mice and other rodent species. It belongs to the family Paramyxoviridae and the genus Pneumovirus. PVM is commonly used as a model for studying viral respiratory infections in mice, providing valuable insights into the mechanisms and progression of pneumonia.
The virus primarily targets the respiratory system, causing severe inflammation and damage to the lungs. PVM is transmitted through direct contact with infected animals, respiratory droplets, or contaminated objects. Once it enters the host's respiratory tract, the virus quickly replicates within the respiratory epithelial cells, leading to a wide range of clinical symptoms.
Typical signs of PVM infection include labored breathing, coughing, sneezing, nasal discharge, and reduced activity levels. In severe cases, mice may exhibit weight loss, increased mortality rates, and pneumonia-like symptoms characterized by lung consolidation.
Research suggests that PVM infection can lead to immunosuppression, making affected mice more susceptible to secondary bacterial infections. To diagnose PVM infection, various methods such as polymerase chain reaction (PCR) tests and serological assays can be employed.
Prevention and control of the Pneumonia Virus of Mice primarily rely on practicing good hygiene and implementing adequate biosecurity measures. Regular screening, quarantine protocols, and strict sanitation strategies can help reduce the risk of transmission within laboratory mouse populations. Additionally, the development of effective vaccines or antiviral treatments may offer potential avenues for combating PVM and minimizing its impact on laboratory mouse research.
