PMN stands for polymorphonuclear leukocytes, also known as neutrophils. Neutrophils are a type of white blood cell that plays a vital role in the immune system's response to infection and inflammation.
PMNs are part of the granulocyte family and are characterized by their multi-lobed nucleus, with each lobe connected by a thin strand of chromatin material. These leukocytes are abundant in the bloodstream and are the first cells to migrate towards infected tissues or sites of inflammation.
When the body is confronted with an infection, PMNs are among the first responders, quickly recruited to the site to engulf and destroy invading microorganisms through a process called phagocytosis. They release potent antimicrobial substances such as reactive oxygen species and antimicrobial peptides, which help neutralize pathogens.
In addition to their role in immunity, PMNs are also involved in the resolution of inflammation and wound healing. They release substances that help recruit other immune cells to the site of infection or injury, stimulate tissue repair processes, and clear cellular debris.
Abnormal PMN counts or dysfunction can be indicative of various health conditions, including infections, autoimmune disorders, and certain cancers. Consequently, measuring PMN levels is a crucial component of blood tests and can provide valuable diagnostic information for healthcare professionals.
In summary, PMN refers to a type of white blood cell known as polymorphonuclear leukocytes or neutrophils, which are essential components of the immune system responsible for combating infections, resolving inflammation, and promoting wound healing.
