How Do You Spell PLECKSTRIN?

Pronunciation: [plˈɛkstɹɪn] (IPA)

Pleckstrin is a protein found in human blood platelets, playing a key role in blood coagulation. The spelling of pleckstrin is derived from the Greek word 'plektein', meaning 'to weave', and the suffix '-rin', which signifies a protein. The pronunciation of pleckstrin is /ˈplɛkstrɪn/, with the stress falling on the first syllable 'pleck', and the second syllable pronounced with the schwa sound 'ə'. The final syllable 'trin' is pronounced with a short 'i' sound.

PLECKSTRIN Meaning and Definition

1. Pleckstrin is a protein found in various organisms, including humans, that plays a crucial role in cellular signaling and regulation. It functions as both an adapter and a regulator protein, facilitating interactions between different molecules within the cell.

   At the molecular level, pleckstrin is characterized by its pleckstrin homology (PH) domain, which allows it to bind to specific molecules and mediate various signaling pathways. This domain has a high affinity for phosphoinositides - a type of lipid found in the cell membrane - and it is through this interaction that pleckstrin participates in intracellular signaling events.

   Pleckstrin's role in signal transduction is diverse and depends on its cellular localization. For instance, in platelet cells, pleckstrin is involved in regulating platelet activation and aggregation, crucial for blood clotting processes. In skeletal muscle cells, it is involved in the regulation of insulin signaling and glucose uptake.

   Additionally, pleckstrin has been implicated in the regulation of cell proliferation, cell survival, and cytoskeletal organization. It also plays a role in diseases such as cancer, where alterations in pleckstrin expression or function can lead to aberrant cell growth and metastasis.

   Overall, pleckstrin is a multifunctional protein that serves as an adapter and regulator in cellular signaling pathways, connecting various molecules and contributing to the overall coordination and regulation of cellular processes.

Common Misspellings for PLECKSTRIN

• oleckstrin
• lleckstrin
• 0leckstrin
• pkeckstrin
• ppeckstrin
• poeckstrin
• plwckstrin
• plsckstrin
• pldckstrin
• plrckstrin
• pl4ckstrin
• pl3ckstrin
• plexkstrin
• plevkstrin
• plefkstrin
• pledkstrin
• plecjstrin
• plecmstrin
• pleclstrin
• plecostrin

Etymology of PLECKSTRIN

The word "pleckstrin" is derived from the Greek word "plektron", which means "a spur" or "an instrument for striking". The suffix "-in" is commonly used in biology to denote a protein. Therefore, "pleckstrin" refers to a protein that is reminiscent of a spur or an instrument for striking.

Plural form of PLECKSTRIN is PLECKSTRINS