PICROTOXIN Meaning and
Definition
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Picrotoxin is a chemical compound derived from plants, specifically from the seeds of the Anamirta cocculus and the Picrorhiza kurroa plants. It is a white crystalline substance that is known for its potent and complex effects on the central nervous system.
Picrotoxin acts as a non-competitive antagonist of the gamma-aminobutyric acid (GABA) receptor, which is responsible for inhibitory signaling in the brain. By binding to the receptor, Picrotoxin prevents the flow of chloride ions, disrupting the normal balance of excitatory and inhibitory neurotransmission. This ultimately leads to a hyperactive state of neuronal firing, causing convulsions or seizures.
Due to its ability to induce seizures, Picrotoxin has been used in laboratory research to study epilepsy and as a tool to study the mechanisms underlying GABA neurotransmission. It has also been used historically as an herbal remedy for various conditions, such as epilepsy, anemia, and rheumatism. However, its use in modern medicine is limited due to its potential toxicity and adverse effects.
In summary, Picrotoxin is a compound derived from plants with potent effects on the central nervous system. It primarily acts as a GABA receptor antagonist, leading to increased neuronal firing and seizures. While it has been used historically for medicinal purposes, caution should be exercised due to its toxicity and potential side effects.
Common Misspellings for PICROTOXIN
- oicrotoxin
- licrotoxin
- -icrotoxin
- 0icrotoxin
- pucrotoxin
- pjcrotoxin
- pkcrotoxin
- pocrotoxin
- p9crotoxin
- p8crotoxin
- pixrotoxin
- pivrotoxin
- pifrotoxin
- pidrotoxin
- piceotoxin
- picdotoxin
- picfotoxin
- pictotoxin
- pic5otoxin
- pic4otoxin
Etymology of PICROTOXIN
The word "Picrotoxin" is derived from Greek roots. "Picros" means "bitter" in Greek, and "toxikon" means "poison". So, "Picrotoxin" literally translates to "bitter poison" in Greek.
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