PH CHROMOSOME Meaning and
Definition
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The term "Ph chromosome" refers to a specific type of abnormal chromosome found in certain types of cancer cells, particularly in a form of leukemia known as chronic myeloid leukemia (CML). It is also known as the Philadelphia chromosome, named after the city where it was discovered.
The Ph chromosome is the result of a genetic mutation that occurs when parts of chromosomes 9 and 22 break off and swap places. This chromosomal abnormality leads to the formation of a shorter chromosome 22, known as the Philadelphia chromosome. The swapped parts contain genes (BCR and ABL1) that fuse together to create a mutated gene called BCR-ABL1.
The presence of the Ph chromosome and the resulting BCR-ABL1 gene fusion play a crucial role in the development and progression of CML. The BCR-ABL1 gene produces a protein that interferes with normal cell growth and division, leading to the excessive production of abnormal white blood cells. This uncontrolled growth of cells is characteristic of CML and causes the symptoms associated with the disease.
Targeted therapies called tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of CML by specifically targeting the BCR-ABL1 protein and inhibiting its activity. These treatments have significantly improved the prognosis for individuals with Ph chromosome-positive CML and have become the standard of care.
In summary, the Ph chromosome refers to a specific abnormal chromosome resulting from a gene fusion between chromosomes 9 and 22, leading to the formation of the BCR-ABL1 gene. Its presence is a hallmark of chronic myeloid leukemia, and targeting the protein produced by this gene fusion has revolutionized the treatment of this disease.
Common Misspellings for PH CHROMOSOME
- oh chromosome
- lh chromosome
- 0h chromosome
- pg chromosome
- pb chromosome
- pn chromosome
- pj chromosome
- pu chromosome
- py chromosome
- ph xhromosome
- ph vhromosome
- ph fhromosome
- ph dhromosome
- ph cgromosome
- ph cbromosome
- ph cnromosome
- ph cjromosome
- ph curomosome
- ph cyromosome
- ph cheomosome
Etymology of PH CHROMOSOME
The term "Ph chromosome" is used in reference to a specific abnormal chromosome that is found in people with chronic myeloid leukemia (CML). It is also known as the Philadelphia chromosome.
The name "Philadelphia chromosome" originates from the city where it was first discovered, Philadelphia, Pennsylvania, by a scientist named Peter C. Nowell and his colleague David A. Hungerford, in the year 1960. They were studying the chromosomes of CML patients and noticed an abnormality in one particular chromosome. This discovery led to a significant advancement in our understanding of cancer genetics.
The "Ph" in Ph chromosome stands for "Philadelphia", reflecting the origin of the research where it was first identified.
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