Persorption is a medical term that describes the process of tiny particles or molecules being absorbed through the mucous membranes of the body, particularly the digestive tract. It refers to the uptake of substances, such as drugs, nutrients, or toxins, through the mucosal lining of organs, instead of the traditional method of absorption through the walls of blood or lymph vessels.
In this context, persorption bypasses the normal routes of absorption and involves direct transfer across the epithelial barrier. The mucous membranes in the body, such as those in the mouth, stomach, intestines, and respiratory tract, have specialized cells that allow for the movement of substances from the external environment into the internal tissues. This process occurs through diffusion or active transport mechanisms.
Persorption is an alternative route through which certain substances can enter the bloodstream or systemic circulation, bypassing the liver. This can have implications for the bioavailability, metabolism, and distribution of drugs or other substances in the body. The term was first coined by the German physiologist, Ludwig Aschoff, in the late 19th century.
While persorption is not as commonly discussed as other modes of absorption, such as passive diffusion or active transport, it remains an important concept in medical and pharmacological research. Understanding persorption and its potential effects on drug delivery and toxicity can aid in the development of more effective and targeted therapeutic approaches.
