PEMPHIGUS VEGETANS Meaning and
Definition
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Pemphigus vegetans is a rare autoimmune disorder characterized by the development of blistering lesions on the skin and mucous membranes. It is classified under a group of diseases known as pemphigus, which are characterized by the formation of blisters due to the destruction of intercellular junctions.
The term "pemphigus vegetans" refers to the specific clinical presentation and morphological features of the condition. The word "pemphigus" originates from the Greek word "pemphix," meaning blister, and "vegetans" refers to the growth or vegetation-like appearance of the lesions.
Individuals affected by pemphigus vegetans typically experience the formation of large, moist, and vegetative-looking lesions, primarily in the groin, axilla, oral mucosa, and perianal area. The blisters may rupture, causing the formation of painful erosions and crusts. These lesions are often associated with a foul-smelling discharge and can lead to significant discomfort and impairment in daily activities.
Pemphigus vegetans is thought to arise from an immune system malfunction, where autoantibodies attack specific proteins present in the skin and mucous membranes. These autoantibodies disrupt the adhesion between skin cells, resulting in the formation of blisters and impaired healing. The exact triggers of this autoimmune response are not well understood, but genetic, environmental, and immunological factors may contribute.
Treatment for pemphigus vegetans usually involves a combination of immunosuppressive drugs, such as corticosteroids, and medications that target specific components of the immune system. Additionally, wound care and good hygiene practices are essential for the management and prevention of secondary infections.
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A chronic p. in which the bullae persist and rupture, papillomatous vegetations springing from the denuded surfaces.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for PEMPHIGUS VEGETANS
Etymology of PEMPHIGUS VEGETANS
The word "pemphigus vegetans" is derived from two different sources.
1. Pemphigus: The term "pemphigus" comes from the Greek word "pemphix" (πεμφίξ), which means "bubble" or "blister". It was first used in ancient Greece to describe a group of blistering autoimmune skin diseases.
2. Vegetans: The term "vegetans" is derived from the Latin word "vegetare", meaning "to make alive" or "to grow". It is used to describe the specific characteristic of pemphigus vegetans, where the blisters and sores have a vegetative or cauliflower-like appearance, indicating a rapid and exuberant growth.
