Pronunciation: [pˈɛl ˈe͡ɪd͡ʒ] (IPA) 
The word "pell age" is spelled with two syllables and the stress falls on the first syllable "pell". The "e" in "pell" is pronounced as a short "e" sound, like in the word "tell". The second syllable "age" is pronounced with a long "a" sound, like in the word "age". The consonant "l" is pronounced strongly in both syllables. The IPA phonetic transcription for "pell age" is /ˈpɛl ˌeɪdʒ/.
PELL AGE is a term used in the field of genetics to describe a rare genetic disorder known as Pellagra-like syndrome and Alacrima. The condition is characterized by the presence of pellagra-like symptoms, which are similar to those observed in individuals affected by pellagra, a vitamin deficiency disorder. Pellagra is caused by a lack of niacin (vitamin B3) in the diet.
The syndrome is marked by several key features, including skin rashes, diarrhea, dementia, and sensitivity to sunlight. In addition, individuals with pell age may also experience alacrima, a condition characterized by a lack of tears. The lack of tears can lead to dryness and irritation of the eyes.
The underlying cause of pell age is a genetic mutation that affects the production or function of a specific protein involved in niacin metabolism. This mutation disrupts the normal breakdown of tryptophan, an amino acid found in food, into niacin. As a result, affected individuals are unable to produce enough niacin, leading to the development of pellagra-like symptoms.
Pell age is a very rare condition, and its precise prevalence is not yet known. The disorder appears to be inherited in an autosomal recessive manner, meaning that affected individuals inherit two copies of the mutated gene, one from each parent who is typically a carrier of the gene.
Currently, there is no cure for pell age, but treatment mainly focuses on managing the symptoms. This typically involves dietary supplementation of niacin and other essential nutrients to help alleviate the symptoms and improve quality of life for affected individuals. Genetic counseling is also recommended for families with a history of pell age to understand the risks of passing on the condition to future generations.
