PEGYLATION Meaning and
Definition
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Pegylation is a chemical modification process in which polyethylene glycol (PEG) molecules are attached to a drug or therapeutic protein. Polyethylene glycol is a biocompatible, water-soluble polymer that has a long hydrophilic chain, which can be attached to the drug or protein via covalent bonding. This process is often used in pharmaceutical and biotechnology industries to enhance the therapeutic properties of drugs and proteins.
The addition of PEG to drugs or proteins through pegylation provides several benefits. First, PEGylation can increase the stability and solubility of the drug or protein, allowing for improved storage and administration. Second, pegylation can increase the bioavailability of the drug, meaning that it can remain in the body for a longer period of time, extending its therapeutic effects. Additionally, PEGylation can reduce the immunogenicity of the drug or protein, minimizing the likelihood of an adverse immune response. This process can also enhance the drug's resistance to enzymatic degradation, allowing for a more controlled release of the therapeutic agent.
Pegylation has been employed in various therapeutic applications, such as in the development of long-acting formulations of drugs, targeted drug delivery systems, and protein-based therapeutics. It has proven particularly useful in improving the efficacy and safety profiles of anticancer drugs, antiviral agents, and biologic drugs. Overall, pegylation offers a versatile strategy to optimize the pharmacokinetics and therapeutic outcomes of drugs and proteins, making it an important tool in the field of drug development.
Common Misspellings for PEGYLATION
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