PASSIVE TRANSFER EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS Meaning and
Definition
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Passive Transfer Experimental Autoimmune Myasthenia Gravis (PT EAMG) refers to a preclinical laboratory model that is used to study and understand the pathophysiology and therapeutic interventions for autoimmune myasthenia gravis (MG). MG is a chronic neuromuscular disorder characterized by muscle weakness and fatigue, resulting from autoantibodies that target and disrupt the communication between nerve cells and muscles.
In PT EAMG, the disease is induced in animal models, typically mice, by transferring pathogenic autoantibodies derived from MG patients or animals with naturally occurring MG. These autoantibodies are injected into healthy animals, which subsequently develop symptoms and pathology similar to MG. This experimental approach is considered a passive transfer because the disease is directly transferred from the antibody donor to the recipient animal, bypassing the need for immune cells to generate autoantibodies.
The PT EAMG model enables researchers to study various aspects of MG, including the underlying immunological mechanisms, the role of specific autoantibodies, and the efficacy of potential therapeutic interventions. By utilizing this model, researchers can evaluate the impact of different factors on disease development, progression, and response to treatment.
Overall, PT EAMG serves as a valuable tool for understanding the pathogenesis of MG and evaluating potential therapies, ultimately contributing to advancements in the diagnosis, treatment, and management of this debilitating autoimmune disorder.
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