PARE PROTEIN Meaning and
Definition
-
ParE protein refers to a type II topoisomerase enzyme found in bacteria that is primarily responsible for resolving DNA tangles and relieving supercoiling during DNA replication and transcription. Also known as DNA gyrase, this protein is an essential component of the bacterial replication machinery.
The ParE protein functions by introducing temporary breaks in double-stranded DNA molecules, called DNA cleavage, to allow the DNA to unwind and relax. It then ligates the broken strands back together, thereby restoring the integrity of the DNA molecule. This process is crucial for regulating DNA topology and maintaining proper chromosomal structure in bacterial cells.
As a type II topoisomerase, ParE protein acts by catalyzing the ATP-dependent change in DNA topology. It utilizes energy from ATP hydrolysis to introduce the necessary torsional stress in the DNA helix, allowing for the unwinding and separation of the intertwined DNA strands. This activity is vital for DNA replication and transcription processes, as it prevents the accumulation of excessive DNA supercoiling, which can impede these essential cellular processes.
ParE protein has been a target for antimicrobial drug development, as its inhibition can lead to DNA damage and subsequent cell death in bacteria. Understanding the structure and function of ParE protein is crucial in developing effective antibiotics that can selectively target bacterial cells while minimizing harm to human cells that lack this specific protein.
Common Misspellings for PARE PROTEIN
- oare protein
- lare protein
- -are protein
- 0are protein
- pzre protein
- psre protein
- pwre protein
- pqre protein
- paee protein
- pade protein
- pafe protein
- pate protein
- pa5e protein
- pa4e protein
- parw protein
- parr protein
- par4 protein
- par3 protein
- pare orotein
- pare lrotein
Infographic
Add the infographic to your website:
