The word "parapedesis" is spelled pəˌræpəˈdiːsɪs in IPA phonetic transcription. This term refers to the passage of white blood cells through the walls of blood vessels into surrounding tissue. The spelling of this word can be broken down into its component syllables: pa-ra-pe-de-sis. Each syllable is pronounced with the stress on the second-to-last vowel, except in the final syllable where the stress is on the first vowel. The combination of vowels and consonants in this word creates a unique sound, making it distinct from other medical terms.
Parapedesis is a medical term that refers to the passage or migration of cells or substances from one tissue or organ to another through the walls of blood vessels or lymphatic vessels. It is a specific type of cellular movement that involves the crossing of these vessel walls, which are normally impermeable to larger particles or cells.
The process of parapedesis usually occurs in response to certain physiological or pathological conditions, such as inflammation or infection. During these situations, the blood vessels become more permeable, allowing various cells and substances to exit or enter the circulation. Specifically, parapedesis allows white blood cells (leukocytes) to leave the bloodstream and migrate to the site of an infection or injury, where they can initiate an immune response to combat foreign invaders or damaged tissue.
Parapedesis involves a series of complex events that include receptor interactions, morphological changes, and adhesion molecule interactions between the cells and the vessel walls. These mechanisms allow the cells or substances to squeeze or pass through the endothelial lining of blood vessels or the endothelial lining of lymphatic vessels.
Overall, parapedesis plays a crucial role in the body's immune response and helps in the regulation of various physiological processes. Its understanding is vital in fields such as immunology, inflammation research, and vascular biology, as it provides insights into the cellular movements that contribute to the body's defense mechanisms and overall health.
Excretion or secretion through an abnormal channel.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "parapedesis" is derived from the Greek roots "para", meaning beside, and "pedesis", meaning a stepping, going, or migration. It is often used in medical or biological context to refer to the migration of cells between tissues or organs.