PAPP A Meaning and
Definition
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Pregnancy-associated plasma protein A (PAPP-A) is a specialized protein that is primarily produced by the developing placenta during pregnancy. It belongs to the family of metalloproteinases, which are enzymes involved in various biological processes. PAPP-A plays a crucial role in pregnancy by regulating several aspects of fetal development and maternal health.
In terms of fetal development, PAPP-A is involved in promoting normal growth and development of the fetus. It accomplishes this by regulating the availability and function of insulin-like growth factor-1 (IGF-1), a hormone that stimulates cell growth and differentiation. PAPP-A assists in the release of biologically active IGF-1 from a protein complex, enhancing the hormone's effectiveness.
PAPP-A is also utilized as a biomarker in prenatal screening tests for genetic abnormalities, particularly Down syndrome. It has been observed that altered levels of PAPP-A are associated with an increased risk of chromosomal abnormalities in the fetus, such as trisomy 21. Therefore, measuring PAPP-A levels during the first trimester of pregnancy can provide valuable information regarding the likelihood of genetic abnormalities.
Additionally, PAPP-A has been implicated in certain pathological conditions, including cardiovascular diseases. Alterations in its expression and function have been associated with atherosclerosis, unstable angina, and myocardial infarction. Research is being conducted to further understand the mechanisms through which PAPP-A may contribute to these conditions, potentially paving the way for novel diagnostic and therapeutic strategies.
In summary, PAPP-A is a protein predominantly produced by the placenta during pregnancy, regulating fetal growth and serving as a biomarker in prenatal screening. Its involvement in various physiological and pathological processes makes it an important subject of scientific investigation.
Common Misspellings for PAPP A
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- xAPP A
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- PAxP A
- PAtP A
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- PAPx A
- PAPt A
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- PAPP e
- PAPP c
Etymology of PAPP A
The term "PAPP-A" stands for Pregnancy-associated plasma protein A. It is an acronym derived from the full name of the protein. The etymology of this specific term is rooted in its function and association with pregnancy. The protein was first identified and isolated from the blood plasma of pregnant women. It was found to be produced by the placenta during pregnancy and was later named "Pregnancy-associated plasma protein A" to reflect its significance in pregnancy-related processes.
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