PALMITOYL THIOESTERASE Meaning and
Definition
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Palmitoyl thioesterase is an enzyme that catalyzes the hydrolysis or cleavage of a palmitoyl thioester bond. A palmitoyl thioester bond is a chemical linkage formed between a palmitic acid molecule and a substrate molecule usually consisting of a protein or a lipid.
The hydrolysis of this bond by palmitoyl thioesterase results in the release of the palmitic acid molecule from the substrate, thereby regulating the modification state of proteins or lipids within cells. Palmitoylation, the process of adding a palmitic acid molecule to a protein or lipid, is a reversible post-translational modification that plays a crucial role in various biological processes, including protein trafficking, membrane localization, signal transduction, and cellular signaling.
Palmitoyl thioesterases are important enzymes that control the dynamics and duration of palmitoylation by removing palmitic acid from modified proteins or lipids. They are classified into different types based on their substrate specificity and subcellular localization. These enzymes are highly conserved across species and are present in various tissues and cell types.
The dysregulation of palmitoyl thioesterase activity can have significant implications for cellular function and contribute to the development of various diseases, including cancer, neurological disorders, and metabolic diseases. Therefore, understanding the structure, function, and regulation of palmitoyl thioesterases is important for elucidating their roles in cellular processes and disease pathogenesis.
Common Misspellings for PALMITOYL THIOESTERASE
- oalmitoyl thioesterase
- lalmitoyl thioesterase
- -almitoyl thioesterase
- 0almitoyl thioesterase
- pzlmitoyl thioesterase
- pslmitoyl thioesterase
- pwlmitoyl thioesterase
- pqlmitoyl thioesterase
- pakmitoyl thioesterase
- papmitoyl thioesterase
- paomitoyl thioesterase
- palnitoyl thioesterase
- palkitoyl thioesterase
- paljitoyl thioesterase
- palmutoyl thioesterase
- palmjtoyl thioesterase
- palmktoyl thioesterase
- palmotoyl thioesterase
- palm9toyl thioesterase
- palm8toyl thioesterase
Etymology of PALMITOYL THIOESTERASE
The word "Palmitoyl Thioesterase" is derived from the following components:
1. Palmitoyl: It is derived from the term "palmitate" which refers to a type of fatty acid known as palmitic acid. Palmitic acid is found abundantly in palm oil hence the name "palmitate".
2. Thioesterase: The term "thioesterase" is formed by combining two components - "thioester" and "-ase".
- Thioester: This component is derived from "thio" indicating the presence of a sulfur atom and "ester" which refers to an organic compound that is formed when an alcohol reacts with an acid. Therefore a thioester is a compound in which a sulfur atom is bonded to an ester group.
- "-ase": The suffix "-ase" is commonly used to indicate an enzyme i.e.
