PALADE PATHWAY Meaning and
Definition
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The Palade pathway, named after George E. Palade, a Romanian-American cell biologist and Nobel laureate, refers to a specific cellular pathway involved in protein synthesis and transportation within eukaryotic cells. Also known as the secretory pathway, it is responsible for the production, processing, and transportation of proteins destined for secretion or insertion into cellular membranes.
The Palade pathway starts with the synthesis of proteins by ribosomes attached to the endoplasmic reticulum (ER). These proteins are initially synthesized as polypeptide chains and are then translocated across the ER membrane for further processing. Within the ER lumen, these proteins undergo various modifications, including folding, glycosylation, and disulfide bond formation, to achieve their functional conformation.
After processing in the ER, the proteins are packaged into vesicles known as transport vesicles and are then transported to the Golgi apparatus. The Golgi apparatus further refines and modifies the proteins before sorting them into specific transport vesicles. These vesicles then carry the proteins to their final destinations, such as the plasma membrane for secretion or various intracellular compartments for specific cellular functions.
Overall, the Palade pathway plays a crucial role in the regulation and coordination of protein synthesis, processing, and transportation, ensuring proper cellular function. Its meticulous orchestration contributes to the maintenance of cell homeostasis and facilitates the secretion of important molecules involved in cell-to-cell communication, immune responses, and overall organismal physiology.
Common Misspellings for PALADE PATHWAY
- oalade pathway
- lalade pathway
- 0alade pathway
- pzlade pathway
- pslade pathway
- pwlade pathway
- pqlade pathway
- pakade pathway
- papade pathway
- paoade pathway
- palzde pathway
- palsde pathway
- palwde pathway
- palqde pathway
- palase pathway
- palaxe pathway
- palace pathway
- palafe pathway
- palare pathway
- palaee pathway
Etymology of PALADE PATHWAY
The term "Palade pathway" is named after George E. Palade, a Romanian-American cell biologist. George Palade made significant contributions to the field of cell biology, particularly in the study of protein synthesis and the structure of the cell organelles. In the 1950s and 1960s, Palade conducted extensive research on the endoplasmic reticulum, a network of membranes within the cell responsible for protein synthesis, modification, and transport.
Palade's groundbreaking work led to the discovery of a new pathway within the endoplasmic reticulum involved in protein synthesis and transport. This pathway, initially known as the "microsomal fraction" or "microsomal system", was later renamed as the "Palade pathway" in honor of George Palade's contributions to the field.
