"p v ras" refers to the PVRAS gene, also known as Poliovirus receptor-related immunoglobulin domain-containing receptor A. It is a gene that codes for a transmembrane protein receptor found on the surface of cells in various tissues of the body. This gene is located on human chromosome X, and it plays a crucial role in various physiological processes, primarily involved in immune responses.
The PVRAS protein is a member of the immunoglobulin superfamily and is structurally similar to the poliovirus receptor (PVR). It functions as a receptor for multiple ligands, including members of the nectin-like protein family, which are involved in cell adhesion and communication. By interacting with these ligands, the PVRAS protein mediates diverse cellular functions, including cell survival, migration, activation, and immune response modulation.
In particular, the PVRAS gene is found to be expressed at high levels in certain immune cells, such as T cells, B cells, and natural killer cells. It is also present in various tissues, including brain, lung, liver, kidney, and intestine, indicating its involvement in different physiological systems.
Mutations or dysregulation in the PVRAS gene have been associated with several diseases, including autoimmune disorders, cancer, and neurological disorders. Therefore, understanding the function of p v ras is essential for elucidating disease mechanisms and developing targeted therapies for various conditions.
