P SELECTIN Meaning and
Definition
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P-selectin, also known as platelet-selectin, is a transmembrane glycoprotein that belongs to the selectin family of cell adhesion molecules. It plays a significant role in the process of inflammation and immune response. P-selectin is primarily expressed on the surface of circulating platelets and endothelial cells, although it can also be found on other leukocytes such as neutrophils and monocytes.
The function of P-selectin is to mediate the adhesion and subsequent recruitment of leukocytes to the site of injury or infection. Upon activation of platelets or endothelial cells, P-selectin is rapidly translocated from its internal storage pools to the cell surface, where it interacts with various ligands expressed on leukocytes. This interaction allows leukocytes to firmly adhere to the endothelial wall and eventually migrate into the underlying tissues.
P-selectin is crucial for the initial rolling and tethering of leukocytes along the blood vessel walls, a vital step in the inflammatory response. Its expression is induced by various inflammatory mediators such as cytokines and chemokines. Furthermore, P-selectin has also been implicated in other physiological and pathological processes, including thrombosis, atherosclerosis, and cancer metastasis.
Due to its involvement in inflammation and immune response, P-selectin has emerged as a therapeutic target in various diseases. Blocking P-selectin interactions with leukocytes can potentially be used to attenuate the inflammatory response and reduce tissue damage. Several drugs and experimental therapies targeting P-selectin are currently being developed and studied for their clinical efficacy.
Common Misspellings for P SELECTIN
Etymology of P SELECTIN
The term "P-selectin" is derived from the protein's function and its selective binding properties. It stands for "platelet selectin" because it was initially discovered on the surface of platelets. "Selectin" refers to a family of cell-adhesion molecules that mediate interactions between cells, particularly during the inflammatory response. Therefore, "P-selectin" specifically refers to a selectin protein found on platelets.
