ORGAN OF ZUCKERKANDL Meaning and
Definition
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The organ of Zuckerkandl is a term used in medical anatomy to refer to a group of neural crest-derived cells or neuroendocrine cells located in the proximity of the aortic bifurcation, adjacent to the origin of the inferior mesenteric artery. It is named after Emil Zuckerkandl, an Austrian anatomist who described and first identified this structure in the late 19th century.
This organ is primarily composed of chromaffin cells, which are responsible for the production and release of various hormones. These hormones include catecholamines like epinephrine and norepinephrine, which contribute to the body's response to stress and regulate blood pressure. The organ of Zuckerkandl is believed to function as a sympathetic paraganglia, serving as an important source of catecholamines in the body.
Anatomically, the organ of Zuckerkandl is located in the retroperitoneum, which lies behind the abdominal cavity. Its position near the aortic bifurcation allows it to receive direct blood supply from the aorta and sympathetic nerve fibers.
While the precise role and functionality of the organ of Zuckerkandl are not yet fully understood, it is thought to play a significant role in the regulation of cardiovascular function and blood pressure. Furthermore, it may also have clinical significance, as tumors can occasionally develop in this region, known as paragangliomas or extra-adrenal pheochromocytomas, which can result in excessive hormone production and hypertension.
