The spelling of the word "orexin" can be explained phonetically with the use of the International Phonetic Alphabet (IPA). The first sound is represented by the symbol "ɔː", which is the long "o" sound. The second sound is represented by the symbol "r", which is the "r" sound. The third and fourth sounds are represented by the symbol "ɛ" and "ks", respectively, which together form the "ecks" sound. Finally, the last sound is represented by the symbol "ɪn", which is the "in" sound. Therefore, the spelling of the word "orexin" can be pronounced as /ɔːrɛksɪn/.
Orexin, also known as hypocretin, refers to a group of neuropeptides that are primarily produced in the lateral hypothalamus of the brain. It plays a crucial role in regulating various physiological processes, particularly those related to arousal, wakefulness, and appetite.
Orexin acts as a neurotransmitter and binds to specific receptors within the central nervous system, including the hypothalamus, brainstem, and other regions of the brain. Its effects are primarily excitatory, meaning it enhances neural activity and promotes wakefulness. By stimulating these regions, orexin promotes alertness, regulates the sleep-wake cycle, and helps to maintain adequate levels of consciousness.
In addition to its role in promoting wakefulness, orexin is also involved in regulating appetite and energy balance. It interacts with other neuropeptides, such as neuropeptide Y and melanin-concentrating hormone, to modulate the feelings of hunger and satiety. Dysfunction of the orexin system has been implicated in sleep disorders, particularly narcolepsy, where individuals experience excessive daytime sleepiness and abnormal rapid eye movement (REM) sleep.
Furthermore, orexin has been shown to be involved in other physiological functions, including regulation of blood pressure, body temperature, pain sensitivity, and cardiovascular functions. Research is ongoing to further understand the complex functions and interactions of orexin in the body, as it holds potential for therapeutic interventions related to sleep disorders, obesity, and other conditions.
Phendihydroquinazolin tannate or hydrochloride, a yellowish white, insoluble, tasteless powder derived from quinoline; employed to increase the appetite in tuberculosis and other wasting diseases, and also as an antiemetic, in doses of gr. 5-10 (0.3-0.6).
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "orexin" is derived from the combination of two words: "orexis" and "in".
"Orexis" is a Greek word that means "appetite" or "desire". It is derived from the verb "orego", which means "to stretch out" or "reach for".
The suffix "-in" is used to form nouns from verbs or adjectives in English. In the case of "orexin", the suffix is likely used to indicate that it is a substance or hormone related to appetite.
Therefore, the etymology of the word "orexin" can be understood as a combination of "orexis" meaning "appetite" and the suffix "-in" indicating a substance or hormone.