Oncornavirus is a term that refers to a group or genus of retroviruses, which are RNA viruses that are capable of reverse transcription to DNA within host cells. These viruses are known for their potential to induce or cause the development of cancerous tumors, particularly in animals.
Oncornaviruses were first identified and extensively studied in the early 20th century, leading to significant advancements in understanding the relationship between viruses and cancer. They have been found to infect a wide range of species, including mammals, birds, and fish, exhibiting a broad host range.
The mechanism by which oncornaviruses induce cancer is through the integration of their genetic material into the host cell's DNA. This integration can disrupt the normal functioning of genes, leading to uncontrolled cell growth and tumor formation. Additionally, oncornaviruses may also encode oncogenes, which are genes that have the potential to transform normal cells into cancerous ones.
Oncornaviruses have been extensively studied in animal models and have provided valuable insights into the mechanisms of cancer development and pathogenesis. In humans, notable examples of oncornaviruses include Human T-cell lymphotropic virus type 1 (HTLV-1) and Human T-cell lymphotropic virus type 2 (HTLV-2), which have been associated with certain types of leukemia and lymphoma.
Understanding oncornaviruses and their role in cancer development has paved the way for the development of targeted therapies and prevention strategies against viral-induced cancers.
The word "Oncornavirus" is derived from two components: "onco-" and "coronavirus".
1. "Onco-" is a prefix that comes from the Greek word "onkos", meaning tumor or mass. It is commonly used in medical terminology to indicate related to or involving cancer.
2. "Coronavirus" is a term coined from the Latin word "corona", meaning crown or halo, and "virus", which refers to an infectious agent capable of replicating within living cells. The name coronavirus is derived from the appearance of the virus particles under an electron microscope, where they resemble a crown or solar corona.
Therefore, when combined, "Oncornavirus" refers to a type of virus that is related to cancer (onco-) and shares some characteristics with coronaviruses. It suggests a potential involvement or association of the virus with cancer development or progression.