How Do You Spell ONCOGENE PROTEIN TPR MET?

Pronunciation: [ˈɒnkə͡ʊd͡ʒˌiːn pɹˈə͡ʊtiːn tˌiːpˌiːˈɑː mˈɛt] (IPA)

The spelling of the word "Oncogene Protein tpr met" can be explained using IPA phonetic transcription. "Oncogene" is pronounced as /ˈɑːŋkəˌdʒiːn/, "Protein" as /ˈproʊtiːn/, "tpr" as /ti pi ɑr/, and "met" as /mɛt/. The term refers to a protein that is encoded by the gene known as tpr-met oncogene. It plays an important role in cell growth and division, and its abnormal functioning has been linked to the development of certain cancers. Proper spelling of scientific terms is crucial for clear communication in research and medical fields.

ONCOGENE PROTEIN TPR MET Meaning and Definition

  1. Oncogene Protein tpr met, also known as TPR-MET or TPMT, is a fusion protein resulting from a chromosomal translocation between the genes TPR (translocated promoter region) and MET (Met proto-oncogene). It is primarily associated with various types of cancer, particularly certain types of solid tumors, including gastric and lung carcinoma.

    This fusion protein consists of the N-terminal coiled-coil domain of TPR fused with the intracellular signaling domain of MET. The coiled-coil domain of TPR mediates protein-protein interactions, while the intracellular domain of MET is responsible for signal transduction, promoting cell proliferation, survival, motility, and invasion.

    The aberrant expression of TPR-MET arises from the fusion of the two genes, resulting in a constitutively activated protein that becomes autonomous of the normal regulatory mechanisms controlling MET activity. This abnormal activation leads to uncontrolled cellular growth and survival, contributing to the development and progression of cancer.

    Importantly, TPR-MET fusion protein is known to activate multiple signaling pathways, such as the Ras, PI3K, and STAT pathways, which further promote cancer growth and metastasis. Due to its crucial role in oncogenesis, TPR-MET has emerged as a target for therapeutic interventions. Understanding the mechanisms by which this fusion protein contributes to cancer progression is essential for the development of novel and effective treatments for cancers associated with TPR-MET expression.

Common Misspellings for ONCOGENE PROTEIN TPR MET

  • incogene protein tpr met
  • kncogene protein tpr met
  • lncogene protein tpr met
  • pncogene protein tpr met
  • 0ncogene protein tpr met
  • 9ncogene protein tpr met
  • obcogene protein tpr met
  • omcogene protein tpr met
  • ojcogene protein tpr met
  • ohcogene protein tpr met
  • onxogene protein tpr met
  • onvogene protein tpr met
  • onfogene protein tpr met
  • ondogene protein tpr met
  • oncigene protein tpr met
  • onckgene protein tpr met
  • onclgene protein tpr met
  • oncpgene protein tpr met
  • onc0gene protein tpr met
  • onc9gene protein tpr met

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