OAT TRANSPORT PROTEINS Meaning and
Definition
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OAT (Organic Anion Transport) proteins are a class of protein transporters located in cell membranes that play a vital role in the transportation of various organic anionic molecules across biological barriers. These proteins are predominantly found in the kidney, liver, intestine, and brain, where they regulate the uptake and elimination of endogenous and exogenous substances. OAT transporters facilitate the movement of a wide range of compounds, including drugs, toxins, hormones, and metabolites, across cell membranes.
OAT transporters belong to the solute carrier (SLC) superfamily of membrane transport proteins and are further classified into two subfamilies based on their location and function: OAT1 and OAT3, which are primarily expressed in kidney cells, and OATP (organic anion transporting polypeptides) subfamily, which is mainly found in the liver and intestine. OAT transporters actively transport organic anionic compounds from the blood into cells or from cells into the blood, thereby regulating their concentration and distribution within the body.
The importance of OAT transporters lies in their ability to mediate the pharmacokinetics and pharmacodynamics of drugs. By facilitating their movement across biological barriers, OAT transporters influence drug absorption, distribution, metabolism, and excretion. Consequently, variations in the expression and activity of OAT transporters can lead to significant changes in drug efficacy, toxicity, and interindividual differences in drug response. Understanding the function and regulation of OAT transporters is crucial for optimizing drug therapy and developing strategies to overcome drug resistance and drug-drug interactions.
Common Misspellings for OAT TRANSPORT PROTEINS
- iat transport proteins
- kat transport proteins
- lat transport proteins
- pat transport proteins
- 0at transport proteins
- 9at transport proteins
- ozt transport proteins
- ost transport proteins
- owt transport proteins
- oqt transport proteins
- oar transport proteins
- oaf transport proteins
- oag transport proteins
- oay transport proteins
- oa6 transport proteins
- oa5 transport proteins
- oat rransport proteins
- oat fransport proteins
- oat gransport proteins
- oat yransport proteins
