The spelling of the term "nude mouse" can be explained using the IPA phonetic transcription. The word "nude" is pronounced as /njuːd/ with the /uː/ vowel sound being pronounced as "oo". The word "mouse" is pronounced as /maʊs/ with the /aʊ/ diphthong pronounced as "ow". Therefore, the correct pronunciation of "nude mouse" is /njuːd maʊs/. This term refers to a type of laboratory mouse that lacks hair due to a genetic mutation, making it easier to study skin diseases and cancer.
A nude mouse is a term used to describe a laboratory mouse strain that lacks a functional immune system due to a genetic mutation. The name "nude" is derived from the mice's characteristic hairless appearance, which is a result of a separate mutation. Nude mice are extensively used in scientific research, particularly in the field of immunology and cancer research.
These mice lack a specific type of immune cells known as T-cells, which are vital for mounting immune responses against foreign substances or diseased cells. As a consequence, nude mice have a severely compromised immune system, making them valuable models for studying human diseases and testing potential treatments.
The hairless mutation in nude mice allows researchers to easily observe and manipulate the growth and development of xenografted human tumors, as the lack of hair provides better visibility and accessibility during experimental procedures. Nude mice are often used in xenotransplantation studies, where human tumor cells or tissues are implanted into the mice to evaluate the effectiveness of new anti-cancer agents.
Due to their unique characteristics, nude mice have become indispensable tools in biomedical research, providing valuable insights into human diseases and treatments. They provide scientists with an opportunity to comprehensively study immune system function, tumor growth, and the effectiveness of various therapeutic interventions.
The term "nude mouse" refers to a specific strain of laboratory mice that lack a coat of fur due to a genetic mutation. The word "nude" in this context is derived from the Latin word "nudus", meaning "naked" or "bare". It describes the absence of fur or hair on the mouse's body, making it appear "nude" in comparison to other mice. The term "nude mouse" was coined in the early 1960s when scientists discovered and began using these hairless mice in biomedical research.