NOGUCHI TEST Meaning and
Definition
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The Noguchi test, also known as the Noguchi IgM test or Noguchi latex test, is a laboratory diagnostic test used to detect antibodies of Treponema pallidum, the bacterium responsible for syphilis infection. It is an immunoassay that employs latex particles coated with antigens derived from T. pallidum to detect the presence of syphilis-specific antibodies, particularly the IgM antibodies.
The Noguchi test is based on the principle of agglutination, where the latex particles coated with T. pallidum antigens agglutinate or clump together in the presence of specific antibodies in the patient's serum. The agglutination reaction can be visually observed as a visible clumping on a glass slide or through turbidity in a test tube. This test is especially useful for the detection of early syphilis infections, as IgM antibodies tend to be produced early in the course of the disease.
In a clinical setting, the Noguchi test is commonly used as a screening tool for syphilis, aiding in the rapid detection and diagnosis of the infection. However, it is important to note that this test may have limitations, and confirmation through additional specific tests, such as the Treponemal test or non-treponemal tests, may be required to eliminate false-positive or false-negative results. Overall, the Noguchi test serves as an essential tool in the diagnosis and management of syphilis, assisting healthcare professionals in providing accurate and timely treatment to patients.
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1. A test for tabes or general paralysis, depending upon a specific albumin reaction of the spinal fluid: o. 1 c.c. of the spinal fluid to be tested is placed in a test-tube whose diameter is 1 cm. or less. To this is added 0.5 c.c. of a 10 per cent, solution of butyric acid. The tube is now heated until the fluid is bubbling, and while still hot o. 1 c.c. of a normal (4 per cent.) solution of sodium hydrate is added. In nearly all spinal fluids an opalescence or cloud occurs, but in the spinal fluid of general paralysis the cloud soon separates into a definite flocculence which is characteristic. 2. A test for syphilis, a modification of the Wassermann method: The antigen is a lipoid substance extracted from the liver and heart; human corpuscles instead of sheep's corpuscles are used, and the hemolytic ambocepter is obtained by immunizing rabbits against normal. human erythrocytes. The hemolytic ambocepter and antigen are preserved by soaking filter paper and drying. The antigen filter paper is placed in human serum, guinea-pig's serum is added and both are diluted with isotonic salt solution; after this has stood a definite time at incubator temperature the hemolytic amboceptor paper and a definite quantity of washed normal human erythrocytes are added. 3. Luetin test, cutireaction test; a drop of luetin is injected intracutaneously, and if syphilis is present a large, reddish indurated papule surrounded with a purplish areola appears within 24 to 48 hours.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for NOGUCHI TEST
- boguchi test
- moguchi test
- joguchi test
- hoguchi test
- niguchi test
- nkguchi test
- nlguchi test
- npguchi test
- n0guchi test
- n9guchi test
- nofuchi test
- novuchi test
- nobuchi test
- nohuchi test
- noyuchi test
- notuchi test
- nogychi test
- noghchi test
- nogjchi test
- nogichi test
Etymology of NOGUCHI TEST
The term "Noguchi test" is derived from the name of Dr. Hideyo Noguchi, a prominent Japanese bacteriologist and physician. Dr. Noguchi conducted extensive research on various diseases, including syphilis. In the early 20th century, he developed a diagnostic test known as the "Noguchi test" for the detection of antibodies to the bacterium that causes syphilis. This test became widely used and played a crucial role in the diagnosis and treatment of syphilis. Due to Dr. Noguchi's significant contributions to the field of medicine, the diagnostic test was named after him.
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