NNRTI Meaning and
Definition
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NNRTI stands for Non-Nucleoside Reverse Transcriptase Inhibitor. It is a class of antiretroviral drugs that specifically targets and inhibits the activity of the reverse transcriptase enzyme of the human immunodeficiency virus (HIV). Reverse transcriptase is crucial for the replication of the virus, as it converts the viral RNA genome into DNA, which can then be incorporated into the host cell's DNA.
NNRTIs work by binding to a specific site on the reverse transcriptase enzyme, known as the NNRTI binding pocket. By attaching to this site, the NNRTI molecules disrupt the catalytic activity of the reverse transcriptase, preventing the conversion of viral RNA into DNA. This inhibition prevents HIV replication and reduces the viral load in the body.
NNRTIs are often used in combination with other antiretroviral drugs as a part of highly active antiretroviral therapy (HAART) to effectively manage HIV infection and slow down the progression of the disease. This class of drugs has demonstrated strong efficacy in reducing HIV viral load and increasing CD4 cell count, thereby improving the immune system's ability to fight against the virus.
NNRTIs are known for their high potency, rapid action, and low risk of drug resistance compared to other classes of antiretrovirals. However, they also have some limitations, such as potential side effects and drug interactions. Therefore, it is essential for healthcare professionals to carefully monitor patients receiving NNRTIs and adjust their treatment regimen accordingly.
Common Misspellings for NNRTI
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