The term "Neurologic Mutant Mouse" refers to a mouse with a genetic mutation affecting its nervous system. The word "neurologic" is spelled as [n(j)ʊəˈrɒlədʒɪk], where the stress is on the second syllable. The IPA phonetic transcription of "mutant" is [ˈmjuːtənt] with the stress on the first syllable. The spelling of "mouse" is straightforward, with the IPA transcription being [maʊs]. The combination of these phonemes results in the correct pronunciation of "n(j)ʊəroʊlɑdʒik ˈmju:tənt maʊs."
Neurologic Mutant Mouse: A neurologic mutant mouse refers to a genetically modified mouse model that has undergone specific alterations in its genetic composition, resulting in neurological structural or functional abnormalities. These abnormalities may involve various aspects of the nervous system, including the brain, spinal cord, or peripheral nerves.
Neurologic mutant mice are engineered through techniques such as gene editing or gene knockout, wherein specific genes associated with neurologic functions are modified or deleted. This intentional genetic manipulation enables researchers to study the role of specific genes or gene pathways in neurodevelopment, neurodegenerative disorders, or other neurological conditions.
These mutant mice often exhibit phenotypic traits that mimic human neurologic disorders or provide insights into underlying molecular mechanisms. The abnormalities observed in neurologic mutant mice can manifest as altered behaviors, abnormal neuronal development, impaired motor coordination, cognitive deficits, or sensory abnormalities. By comparing the behavior and physiological characteristics of these mutant mice to normal mice, scientists can gain a better understanding of the genes and biochemical processes involved in normal neural functions.
Neurologic mutant mouse models have proven to be invaluable tools in neuroscience research, allowing scientists to investigate the complex interplay between genes, neural circuits, and behavior. These mouse models have the potential to provide crucial insights into the pathogenesis of various neurologic diseases and aid in the development of new therapeutic interventions.