Neurogenic inflammation is a term used to describe inflammation caused by nerve fibers. The word "neurogenic" is pronounced /n(j)ʊərəʊˈdʒɛnɪk/ and comes from the Greek word "neuron" meaning nerve, and "genesis" meaning creation. The word "inflammation" is pronounced /ɪnfləˈmeɪʃən/ and refers to the body's response to injury or infection, which can cause redness, swelling, and pain. Combining these two words forms "neurogenic inflammation," which describes how nerves can contribute to the inflammation response.
Neurogenic inflammation is a physiological process characterized by the release of inflammatory mediators in response to neuronal activation or injury within the peripheral nervous system. It occurs as a result of the interaction between sensory nerve fibers, immune cells, and blood vessels.
When peripheral nerves are stimulated or injured, there is a release of neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) from sensory nerve endings. These neuropeptides play a crucial role in initiating and maintaining the inflammatory response. They bind to specific receptors on blood vessels, leading to vasodilation and increased blood flow to the affected area. This increased blood flow helps to deliver immune cells, such as leukocytes, to the site of injury or inflammation.
Neurogenic inflammation is associated with a variety of conditions, including pain syndromes, allergic reactions, and inflammatory diseases of the skin and respiratory tract. It contributes to the symptoms of these conditions by promoting vasodilation, increasing vascular permeability, and attracting immune cells to the affected area.
Treating neurogenic inflammation often involves targeting the release or the effects of neuropeptides. This can be achieved through the use of medication that blocks neuropeptide receptors or inhibits their release. Additionally, non-pharmacological interventions like physical therapy or relaxation techniques may also be employed to manage symptoms associated with neurogenic inflammation.
The word "neurogenic" is derived from the combining form "neuro-" which refers to the nervous system and the Greek word "genēs" meaning "born" or "producing". In this context, "neurogenic" pertains to originating or influenced by the nervous system.
The term "inflammation" comes from the Latin word "inflammare" which means "to set on fire". It refers to a biological response to injury or infection, characterized by redness, swelling, heat, and pain in the affected area.
When combined, "neurogenic inflammation" refers to the process in which the nervous system triggers an inflammatory response, typically involving the release of inflammatory mediators, in response to certain stimuli.