NEUROFIBROMIN Meaning and
Definition
-
Neurofibromin is a protein that plays a crucial role in regulating cell growth and division, as it acts as a tumor suppressor. It is encoded by the NF1 gene, which is found on chromosome 17. Neurofibromin is primarily expressed in nervous tissue and acts as a regulator of the Ras protein signaling pathway.
The Ras pathway is a complex network involved in transmitting signals from cell surface receptors to the cell nucleus, thus influencing various cellular processes such as cell proliferation, differentiation, and survival. Neurofibromin acts as a negative regulator of this pathway by increasing the activity of the GTPase activity of Ras.
Mutations in the NF1 gene, and consequently in neurofibromin, can lead to a genetic disorder called neurofibromatosis type 1 (NF1). Individuals with NF1 may exhibit various symptoms, including the development of benign tumors called neurofibromas, café-au-lait spots on the skin, and abnormalities in bone development. These symptoms are a result of the dysregulation of cell growth and division caused by the absence or malfunctioning of neurofibromin.
Understanding the function and regulation of neurofibromin is essential in providing insights into the pathogenesis of NF1 and developing targeted therapies for this disorder. Additionally, neurofibromin's role in the Ras pathway makes it an intriguing protein for studying various cellular processes and their implications in other diseases.
Common Misspellings for NEUROFIBROMIN
- beurofibromin
- meurofibromin
- jeurofibromin
- heurofibromin
- nwurofibromin
- nsurofibromin
- ndurofibromin
- nrurofibromin
- n4urofibromin
- n3urofibromin
- neyrofibromin
- nehrofibromin
- nejrofibromin
- neirofibromin
- ne8rofibromin
- ne7rofibromin
- neueofibromin
- neudofibromin
- neufofibromin
- neutofibromin
Etymology of NEUROFIBROMIN
The word "neurofibromin" can be broken down into two parts: "neuro" and "fibromin".
- "Neuro" comes from the Greek word "neuron", meaning "nerve". This term is commonly used in scientific and medical contexts related to the nervous system.
- "Fibromin" is a combination of "fibro" and "min". "Fibro" is derived from the Latin word "fibra", meaning "fiber" or "tissue", referring to connective tissue. "Min" is short for "minimum", representing a minimal or essential portion of something.
By combining these parts, "neurofibromin" suggests a substance or molecule that is related to the nerve tissue and its minimal or essential components. This term is specifically used in the context of neurofibromatosis I, a genetic disorder characterized by the development of tumors along nerves and skin.
Infographic
Add the infographic to your website:
