NEUROFIBRILLARY Meaning and
Definition
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Neurofibrillary refers to a characteristic pathological alteration that occurs inside neurons, particularly within the brain of individuals affected by neurodegenerative disorders like Alzheimer's disease. It is a compound term that consists of two components: "neuro," which refers to the nervous system, and "fibrillary," which denotes something that is fibrous or resembling fibers.
The term neurofibrillary is primarily associated with the abnormal accumulation and tangling of protein filaments, called neurofibrillary tangles, within the cell bodies and processes of neurons. These tangles are composed mainly of a protein called tau, which under normal circumstances helps provide structure and stability to the internal transport system of neurons. However, in neurodegenerative diseases, tau becomes highly phosphorylated, meaning it undergoes chemical modifications that cause it to become excessively entangled, leading to the formation of neurofibrillary tangles.
The presence of neurofibrillary tangles is a characteristic pathological feature observed upon examination of brain tissue from individuals with neurodegenerative disorders like Alzheimer's disease. These tangles disrupt the normal functioning of neurons and have been implicated in the progressive degeneration and death of brain cells, contributing to the cognitive decline and memory loss often experienced by affected individuals.
In summary, neurofibrillary refers to the abnormal accumulation of protein filaments known as neurofibrillary tangles, primarily composed of tau, within neurons. These tangles are a hallmark of neurodegenerative diseases and play a significant role in the progressive deterioration of brain function associated with such conditions.
Common Misspellings for NEUROFIBRILLARY
- beurofibrillary
- meurofibrillary
- jeurofibrillary
- heurofibrillary
- nwurofibrillary
- nsurofibrillary
- ndurofibrillary
- nrurofibrillary
- n4urofibrillary
- n3urofibrillary
- neyrofibrillary
- nehrofibrillary
- nejrofibrillary
- neirofibrillary
- ne8rofibrillary
- ne7rofibrillary
- neueofibrillary
- neudofibrillary
- neufofibrillary
- neutofibrillary
Etymology of NEUROFIBRILLARY
The word "neurofibrillary" is derived from two main components: "neuro" and "fibrillary".
1. "Neuro" comes from the Greek word "neuron", meaning nerve. It is commonly used as a prefix in words related to the nervous system or brain.
2. "Fibrillary" comes from the noun "fibril", which is a small fiber or thread-like structure. It is derived from the Latin word "fibra", meaning fiber.
When combined, "neurofibrillary" refers to something related to nerve fibers or thread-like structures within the nervous system.
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