NEOANTIGEN Meaning and
Definition
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Neoantigen, also known as neo-epitope, refers to a type of antigen that is generated through genetic mutations or alterations specifically found in tumor cells. It is a unique molecular target that is absent in normal cells, making it a promising target for immunotherapy and personalized cancer treatment.
Neoantigens arise from somatic mutations in the tumor genome, leading to the expression of mutated proteins on the tumor cell surface. These peptides are presented on the Major Histocompatibility Complex (MHC) molecules and serve as signals to the immune system to recognize and eliminate abnormal cells. Due to their tumor-specific nature, neoantigens have gained substantial attention as potential immunotherapeutic targets.
The identification and characterization of neoantigens have been made possible by the development of high-throughput sequencing technologies and computational tools. Through personalized approaches, such as tumor exome or whole-genome sequencing and subsequent analysis, neoantigens can be identified for individual patients, paving the way for personalized cancer vaccines and immune-based therapies.
Neoantigens have exhibited significant potential in eliciting specific and robust immune responses against tumors, leading to tumor regression and improved patient outcomes. Furthermore, neoantigens represent a dynamic landscape, as they can evolve over time due to the emergence of resistant tumor cell clones. Hence, ongoing research and understanding of neoantigens contribute to the development of innovative therapies that aim to harness the patient's immune system in the fight against cancer.
Common Misspellings for NEOANTIGEN
- beoantigen
- meoantigen
- jeoantigen
- heoantigen
- nwoantigen
- nsoantigen
- ndoantigen
- nroantigen
- n4oantigen
- n3oantigen
- neiantigen
- nekantigen
- nelantigen
- nepantigen
- ne0antigen
- ne9antigen
- neozntigen
- neosntigen
- neowntigen
- neoqntigen
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