Nefopam is a non-opioid analgesic medication that is primarily used in the treatment of moderate to severe pain, including postoperative pain. It is classified as a centrally acting analgesic, indicating that it works by affecting the central nervous system rather than targeting the site of pain directly. Nefopam is believed to inhibit the reuptake of certain neurotransmitters, including serotonin, norepinephrine, and dopamine, leading to enhanced pain relief.
This medication is available in tablet form and is usually taken orally. It is well-absorbed by the gastrointestinal tract and has a relatively fast onset of action, with pain relief typically occurring within 15 to 30 minutes after administration. The duration of its analgesic effects can vary, averaging around 4 to 6 hours.
Nefopam is characterized by its unique pharmacological profile, distinct from opioids or nonsteroidal anti-inflammatory drugs (NSAIDs). It offers pain relief without the risk of respiratory depression or potential for addiction associated with opioids. Additionally, it does not possess the anti-inflammatory properties of NSAIDs.
While generally well-tolerated, nefopam may cause certain side effects, including dry mouth, dizziness, drowsiness, and blurred vision. It is not recommended for use in individuals with a history of seizures, glaucoma, or severe liver or kidney dysfunction. As with any medication, it is essential to follow the prescribed dosage and consult with a healthcare professional for guidance.
