NAKED DNA VACCINES Meaning and
Definition
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Naked DNA vaccines are a type of genetic vaccine that uses fragments of DNA molecules as the main component for immunization. These vaccines are designed to stimulate an immune response by introducing specific genes into the body, which then encode antigens that trigger an immune response against a particular disease-causing organism or agent.
The term "naked" refers to the fact that the DNA used in these vaccines is delivered directly without being encapsulated in a viral or bacterial carrier. This is in contrast to traditional vaccines that often rely on attenuated or inactivated viruses or bacteria to deliver antigens. Instead, naked DNA vaccines typically consist of plasmid DNA, which is a circular DNA molecule that can be easily replicated within bacterial cells.
The immunization process begins by injecting the naked DNA vaccine into the body, typically through intramuscular injection. Once inside the host, the DNA molecules are taken up by cells and are subsequently transcribed and translated to produce the desired antigenic proteins. These proteins are then presented on the surface of cells, allowing the immune system to recognize and mount an immune response against them.
Naked DNA vaccines hold several advantages over traditional vaccines, including their potential to induce a broad immune response involving both cellular and humoral immunity. They are relatively simple and cost-effective to produce, and they do not pose the risk of generating infectious viral particles. However, their use in humans is still under development, and further research is required to assess their safety and efficacy for widespread use.
Common Misspellings for NAKED DNA VACCINES
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