MYB ONCOGENE Meaning and
Definition
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The term "myb Oncogene" refers to a specific gene that is part of the larger oncogene family known as v-myb avian myeloblastosis viral oncogene homolog. The myb gene is found in many species, including humans, and plays a significant role in the development and progression of various cancers, particularly in hematopoietic cells.
The myb oncogene is responsible for encoding a transcription factor protein known as c-Myb. This protein is involved in regulating the expression of other genes, controlling important cell processes such as cell growth, proliferation, differentiation, and apoptosis. When the myb gene is altered or mutated, it can lead to overexpression or hyperactivation of the c-Myb protein, which in turn can promote uncontrolled cell division and contribute to the development of cancer.
Research has shown that the myb oncogene is associated with several types of cancers, including acute myeloid leukemia (AML), colorectal cancer, breast cancer, and prostate cancer. It has also been implicated in the pathogenesis of other hematopoietic disorders, such as myelodysplastic syndrome.
Understanding the role of the myb oncogene in cancer is crucial for the development of targeted therapies and potential treatment options. Targeting the c-Myb protein or its downstream signaling pathways may offer potential therapeutic strategies in combating cancers associated with myb oncogene dysregulation.
Common Misspellings for MYB ONCOGENE
- nyb oncogene
- kyb oncogene
- jyb oncogene
- mtb oncogene
- mgb oncogene
- mhb oncogene
- mub oncogene
- m7b oncogene
- m6b oncogene
- myv oncogene
- myn oncogene
- myh oncogene
- myg oncogene
- myb incogene
- myb kncogene
- myb lncogene
- myb pncogene
- myb 0ncogene
- myb 9ncogene
- myb obcogene
Etymology of MYB ONCOGENE
The word "myb" in oncogene refers to the cellular proto-oncogene called MYB. The etymology of the term MYB traces back to the discovery of avian myeloblastosis virus (AMV) by scientists in the mid-20th century.
In the 1960s, researchers found that AMV could induce the formation of tumors in chickens. Further investigation led to the identification of a specific component within the virus that was responsible for this cancer-causing ability. This component was named the v-Myb oncogene.
Later, through studying normal cells, it was discovered that the viral oncogene had a cellular counterpart. This normal, non-mutated gene responsible for cell growth regulation was designated as c-Myb (c stands for "cellular").
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