MRL LPR MOUSE Meaning and
Definition
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The MRL lpr mouse refers to a specific strain or line of laboratory mice that carry a particular genetic mutation. MRL stands for "Murphy Roths Large", which is the name of the research facility where these mice were bred. Lpr is short for "lymphoproliferation", indicating a spontaneous overgrowth of lymphocytes.
The MRL lpr mouse is commonly used in biomedical research as a model for studying autoimmune diseases, particularly systemic lupus erythematosus (SLE). These mice possess a mutation in a gene called Fas, which is vital for regulating cell death. As a result of this mutation, the MRL lpr mice experience abnormal lymphocyte survival, leading to the accumulation of immune cells and subsequent development of lupus-like symptoms.
These mice exhibit various features similar to human SLE, such as the production of autoantibodies, immune system dysfunction, and organ damage. Researchers utilize the MRL lpr mouse model to investigate the pathogenesis of SLE and test potential therapeutic interventions.
Due to their genetic background, the MRL lpr mice are highly susceptible to autoimmune disorders, making them valuable tools for studying disease mechanisms and evaluating potential treatments. By observing the development and progression of lupus-like symptoms in these mice, researchers can gain insights into the underlying processes of human SLE and identify promising avenues for therapeutic development.
Common Misspellings for MRL LPR MOUSE
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