Correct spelling for the English word "most mussedup" is [mˈə͡ʊst mˈʌsɪdˌʌp], [mˈəʊst mˈʌsɪdˌʌp], [m_ˈəʊ_s_t m_ˈʌ_s_ɪ_d_ˌʌ_p] (IPA phonetic alphabet).
The phrase "most mussed up" is an informal colloquial variation of the term "messed up".
"Mussed up" originated from the verb "muss", which was used in the early 20th century meaning "to make untidy or tousled". The term likely derived from the dialectal word "muss" meaning "to handle or rumple", which was used in the mid-19th century and was possibly of Scandinavian origin.
The addition of "most" to form "most mussed up" is simply an intensifier, emphasizing the extent or degree of being "messed up" or untidy.