The correct spelling of the word "most handcuffed" is /moʊst hændkʌft/. The word "most" is spelled with the letter "o" pronouncing the "ow" sound, followed by the "s" pronounced as a "z" sound. "Handcuffed" is spelled with "hand" pronounced with the "æ" sound, followed by "cuffed" pronounced with the "ʌ" sound. This word refers to someone who has been restrained with handcuffs more than anyone else in a particular context, such as within a police department or in a particular area.