The word "most calculous" is a rather uncommon term in English, referring to the presence of calculi or kidney stones. It is pronounced as /moʊst kælkjʊləs/ with the stress on the first syllable. The IPA phonetic transcription breaks down the pronunciation into the following sounds: /m-oh-s-t/ for "most", and /k-ae-l-k-y-oo-l-uh-s/ for "calculous". While the spelling of the word may seem daunting, its phonetic breakdown helps to ease pronunciation for readers and speakers alike.